| Catalog No. | Size | Price (USD) |
| 10957-RP01-50 | 50 µL | $340.51 |
| 10957-RP01-100 | 100 µL | $147.96 |
| 10957-RP01-200 | 200 µL | $251.64 |
| 10957-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-Acid Phosphatase/ACP1 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Acid Phosphatase/ACP1 |
| Immunogen | Recombinant Human ACP1 / LMW-PTP Protein (Catalog#10957-H09E) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human ACP1 / LMW-PTP (rh ACP1 / LMW-PTP; Catalog#10957-H09E; AAI06012.1; Met1-His158). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-HAAP Antibody; Anti-LMW-PTP Antibody; Anti-LMWPTP Antibody
Background Information
| Full Name | acid phosphatase 1, soluble |
| Description | The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1/LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphorylate activated PDGF receptor, thus modulating PDGF-induced mitogenesis. In vitro, LMW-PTP was found to efficiently dephosphorylate activated FcgammaRIIA and LAT, but not Syk or phospholipase Cgamma2. The overexpression of LMW-PTP inhibited activation of Syk downstream of FcgammaRIIA and reduced intracellular Ca(2+) mobilization. It been demonstrated that LMW-PTP is responsible for FcgammaRIIA dephosphorylation, and is implicated in the down-regulation of cell activation mediated by this ITAM-bearing immunoreceptor. In addition, ACP1 is a highly polymorphic phosphatase that is especially abundant in the central nervous system and is known to be involved in several signal transduction pathways. |
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