Anti-ADAMTS13 Antibody, Rabbit Polyclonal sinobiological 203702-T08
$243.00
In stock
SKU
203702-T08
| Catalog No. | Size | Price (USD) |
| 203702-T08-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-ADAMTS13 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ADAMTS13 |
| Immunogen | E. coli-derived Human Adamts13 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human Adamts13 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human Adamts13 in human liver with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Adamts13 Immunohistochemistry(IHC) 41514 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human Adamts13 in human liver with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human Adamts13 Immunohistochemistry(IHC) 41515 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human Adamts13 in human liver with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 3 Alt Text | Human Adamts13 Immunohistochemistry(IHC) 41516 |
| Image 3 URL | Source image |
Background Information
| Description | ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, 13), also known as the von Willebrand factor-cleaving protease (VWFCP), is a metalloprotease responsible for cleavage of ultra-large von Willebrand factor (VWF) multimers. It is well-known that dysfunction of ADAMTS13 is associated with diverse diseases, such as thrombotic thrombocytopenic purpura, pre-eclampsia, acute myocardial infarction, and diabetes. ADAMTS13 is primarily synthesized by hepatic stellate cells (HSCs), and mainly regulates thrombogenesis by cleaving VWF. ADAMTS13 also plays a role in the down-regulation of inflammation, regulation angiogenesis, and degradation of extracellular matrix. |
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