| Catalog No. | Size | Price (USD) |
| 12856-RP01-100 | 100 µL | $147.96 |
| 12856-RP01-200 | 200 µL | $251.64 |
| 12856-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-ALDH4A1 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ALDH4A1 |
| Immunogen | Recombinant Human ALDH4A1 protein (Catalog#12856-H20B) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human ALDH4A1 (rh ALDH4A1; Catalog#12856-H20B; AAH07581.1; Lys25-Gln563). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ALDH4 Antibody; Anti-P5CD Antibody; Anti-P5CDh Antibody
Background Information
| Full Name | aldehyde dehydrogenase 4 family, member A1 |
| Description | ALDH4A1 is a member of the aldehyde dehydrogenase family. Aldehyde dehydrogenase enzymes function in the metabolism of many molecules including certain fats (cholesterol and other fatty acids) and protein building blocks (amino acids). Additional aldehyde dehydrogenase enzymes detoxify external substances, such as alcohol and pollutants, and internal substances, such as toxins that are formed within cells. ALDH4A1 is expressed abundantly in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas. It is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2). HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation. |
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