| Catalog No. | Size | Price (USD) |
| 10583-T48-50 | 50 µL | $147.96 |
| 10583-T48-100 | 100 µL | $251.64 |
| 10583-T48-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-ALK4/ACVR1B Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ALK4/ACVR1B No cross-reactivity in ELISA with Human cell lysate (293 cell line) |
| Immunogen | Recombinant Human ALK-4 / ACVR1B protein (Catalog#10583-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human ALK-4 / ACVR1B (rh ALK-4 / ACVR1B; Catalog#10583-H08H; NP_004293.1; Met1-Glu126). ALK-4 / ACVR1B specific IgG was purified by Human ALK-4 / ACVR1B affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ACTRIB Antibody; Anti-ACVRLK4 Antibody; Anti-ALK4 Antibody; Anti-SKR2 Antibody
Image / Experimental Information
| Image 1 Description | Anti-ALK4 rabbit polyclonal antibody at 1:500 dilution Lane A: Mouse kidney Tissue Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:57 kDa Observed band size:54 kDa |
| Image 1 Alt Text | Human ALK-4 / ACVR1B Western blot (WB) 6612 |
| Image 1 URL | Source image |
Background Information
| Full Name | activin A receptor, type IB |
| Description | ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination. |
| References |
|
-HB08FE2802-WB.png){kind=link}