Anti-Aminopeptidase A Antibody, Rabbit Polyclonal sinobiological 10554-T24

$243.00
In stock
SKU
10554-T24
Catalog No.SizePrice (USD)
10554-T24-100100 µL$251.64

General Information

Product nameAnti-Aminopeptidase A Antibody, Rabbit Polyclonal
Validated applicationsELISA (FAQ Protocol), IHC-P (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman Aminopeptidase A
ImmunogenRecombinant Human Aminopeptidase A Protein (Catalog#10554-H07B)
PreparationProduced in rabbits immunized with purified, recombinant Human Aminopeptidase A (rh Aminopeptidase A; Catalog#10554-H07B; NP_001968.3; Arg41-Gly957). Aminopeptidase A specific IgG was purified by Human Aminopeptidase A affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-APA Antibody; Anti-CD249 Antibody; Anti-gp160 Antibody

Image / Experimental Information

Image 1 DescriptionImmunochemical staining of human Aminopeptidase A in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
Image 1 Alt TextHuman Aminopeptidase A Immunohistochemistry(IHC) 42639
Image 1 URLSource image
Image 2 DescriptionImmunochemical staining of human Aminopeptidase A in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
Image 2 Alt TextHuman Aminopeptidase A Immunohistochemistry(IHC) 42640
Image 2 URLSource image

Background Information

Full Nameglutamyl aminopeptidase
DescriptionENPEP, also known as aminopeptidase A, is a member of the peptidase M1 family. Members of this family are involved in response to cadmium ion and proteolysis. They located in 6 components and are expressed in 26 plant structures. ENPEP is expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. It also can be detected in a variety of other tissues. ENPEP probably plays a role in regulating growth and differentiation of early B-lineage cells. It also may play a role in the catabolic pathway of the renin-angiotensin system. ENPEP is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. It degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.
References
  1. Speth RC, et al. (2008) The significance of brain aminopeptidases in the regulation of the actions of angiotensin peptides in the brain. Heart Fail Rev. 13(3):299-309.
  2. Rose JE, et al. (2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol Med. 16(7-8):247-53.
  3. Pérez I, et al. (2009) Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma. Head Neck. 31(10):1335-40.

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