Recombinant Human APLP1 / Amyloid-like protein 1 protein (Catalog#13716-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human APLP1 / Amyloid-like protein 1 (rh APLP1 / Amyloid-like protein 1; Catalog#13716-H08H; P51693-1; Met1-Glu580). APLP1 / Amyloid-like protein 1 specific IgG was purified by Human APLP1 / Amyloid-like protein 1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Synonyms: Anti-APLP Antibody
Background Information
Full Name
amyloid beta (A4) precursor-like protein 1
Description
APLP1, also known as amyloid-like protein 1, is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. APLP1, together with APLP2, are important modulators of glucose. APLP1 may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. APLP1 also is a mammalian homologue of amyloid precursor protein (APP). APP is a type I membrane protein that is genetically linked to Alzheimer's disease.
References
Wasco W. et al., 1993, Genomics. 15 (1): 237-9.
Needham BE. et al., 2008, J Pathol. 215 (2): 155-63.
Bayer TA. et al., 2000, Mol Psychiatry. 4 (6): 524-8.
Lee S. et al., 2011, Biochemistry. 50 (24): 5453-64.