Anti-APOBEC3B Antibody, Rabbit Polyclonal sinobiological 102807-T32
$243.00
In stock
SKU
102807-T32
| Catalog No. | Size | Price (USD) |
| 102807-T32-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-APOBEC3B Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human APOBEC3B |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the Human APOBEC3B |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human APOBEC3B, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-A3B Antibody; Anti-APOBEC1L Antibody; Anti-ARCD3 Antibody; Anti-ARP4 Antibody; Anti-bK150C2.2 Antibody; Anti-DJ742C19.2 Antibody; Anti-FLJ21201 Antibody; Anti-PHRBNL Antibody
Image / Experimental Information
| Image 1 Description | Anti-APOBEC3B rabbit polyclonal antibody at 1:500 dilution Lane A: HepG2 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:46 kDa Observed band size:50 kDa |
| Image 1 Alt Text | Human APOBEC3B Western blot (WB) 38731 |
| Image 1 URL | Source image |
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Background Information
| Description | The APOBEC3 DNA cytosine deaminase family comprises a fundamental arm of the innate immune response and is best known for retrovirus restriction. Several APOBEC3 enzymes restrict HIV-1 and related retroviruses by deaminating viral cDNA cytosines to uracils compromising viral genomes. Human APOBEC3B (A3B) shows strong virus restriction activities in a variety of experimental systems, and is subjected to tight post-translational regulation evidenced by cell-specific HIV-1 restriction activity and active nuclear import. The APOBEC3B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate immunity but is also a major endogenous source of mutations in cancer. APOBEC3 (A3B) protein families, a DNA cytidine deaminase, were up-regulated in multiple tumors. A3B is essential for oncogenesis of HCC, and is a potential target for preventive intervention. A common large deletion in the APOBEC3 cluster (the APOBEC3B deletion) may increase the risk of breast cancer. |
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