| Catalog No. | Size | Price (USD) |
| 100901-T08-50 | 50 µL | $147.96 |
| 100901-T08-100 | 100 µL | $251.64 |
| 100901-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Argonaute 4/Ago4 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Argonaute 4/Ago4 |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human Ago4 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human Ago4, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-AGO4 Antibody; Anti-EIF2C4 Antibody; Anti-FLJ20033 Antibody; Anti-hAGO4 Antibody; Anti-KIAA1567 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human AGO4 in human testis with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human Ago4 Immunohistochemistry(IHC) 4736 |
| Image 1 URL | Source image |
Background Information
| Full Name | argonaute 4, RISC catalytic component |
| Description | The four mammalian Argonaute family members are thought to share redundant functions in the microRNA pathway, yet only AGO2 possesses the catalytic "slicer" function required for RNAi. Argonaute (AGO) proteins are core components of small RNA-induced silencing pathways, which negatively regulate gene expression in a sequence-specific manner. In the post-transcriptional gene silencing (PTGS) pathway, AGO proteins bind to small RNAs such as miRNAs, tasiRNAs, or piRNAs and mediate gene silencing through degradation and/or translational suppression of the target mRNAs. AGO proteins are highly conserved and present in various life forms ranging from Archaea to humans. Each AGO protein is characterized by three conserved domains: PAZ, MID, and PIWI. The PAZ domain recognizes and binds the 3- end of small RNAs. |
| References |
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