| Catalog No. | Size | Price (USD) |
| 103473-T08-50 | 50 µL | $147.96 |
| 103473-T08-100 | 100 µL | $251.64 |
| 103473-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-ARHGAP11B Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ARHGAP11B |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human ARHGAP11B |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human ARHGAP11B, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-B'-T Antibody; Anti-FAM7B1 Antibody; Anti-GAP (1-8) Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human ARHGAP11B in human skeletal muscle with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human ARHGAP11B Immunohistochemistry(IHC) 17805 |
| Image 1 URL | Source image |
Background Information
| Description | ARHGAP11B has the highest degree of radial glia-specific expression. ARHGAP11B arose from partial duplication of ARHGAP11A (which encodes a Rho guanosine triphosphatase-activating protein) on the human lineage after separation from the chimpanzee lineage. Expression of ARHGAP11B in embryonic mouse neocortex promotes basal progenitor generation and self-renewal and can increase cortical plate area and induce gyrification. Hence, ARHGAP11B may have contributed to evolutionary expansion of human neocortex. Novel human-specific duplicated genes, ARHGAP11B and SRGAP2C, have recently been described with a potential role in neocortical expansion and increased neuronal spine density. |
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