| Catalog No. | Size | Price (USD) |
| 101309-T32-50 | 50 µL | $147.96 |
| 101309-T32-100 | 100 µL | $251.64 |
| 101309-T32-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-ATP1B3 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ATP1B3 |
| Immunogen | A synthetic peptide corresponding to the center region of the Human ATP1B3/CD298 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human ATP1B3/CD298, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ATPB-3 Antibody; Anti-CD298 Antibody; Anti-FLJ29027 Antibody
Image / Experimental Information
| Image 1 Description | Anti-CD298 rabbit polyclonal antibody at 1:500 dilution Lane A: Hela Whole Cell Lysate Lane B: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:32 kDa Observed band size:32 kDa (We are unsure as to the identity of these extra bands.) |
| Image 1 Alt Text | Human Na,K-ATPase 3 subunit/ATP1B3 Western blot (WB) 6584 |
| Image 1 URL | Source image |
Background Information
| Full Name | ATPase, Na+/K+ transporting, beta 3 polypeptide |
| Description | Enterovirus 71 (EV71) infection can cause severe diseases, and is becoming increasingly common in children. Human beta3 subunit of Na(+)/K(+)-ATPase (ATP1B3) protein was demonstrated to interact with the 3A protein of EV71. Although 3A protein had no effect on the expression of ATP1B3, EV71 infection resulted in elevated expression of ATP1B3 in RD cell line, both on messenger RNA (mRNA) and protein levels. And knockdown of ATP1B3 could significantly increase the replication of EV71, whereas overexpression of ATP1B3 significantly suppressed the replication of EV71 in RD cells. That the expression of ATP1B3 could induce the production of type-I interferons. ATP1B3 inhibit EV71 replication by enhancing the production of type-I interferons, which could act as a potential therapeutic target in EV71 infection. |
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