| Catalog No. | Size | Price (USD) |
| 10279-RP01-100 | 100 µL | $147.96 |
| 10279-RP01-200 | 200 µL | $251.64 |
| 10279-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-AXL Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human AXL |
| Immunogen | Recombinant Human AXL protein (Catalog#10279-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human AXL (rh AXL; Catalog#10279-H08H; AAB20305.1; Met 1-Pro 449). Total IgG was purified by Protein A affinity chromatography . |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ARK Antibody; Anti-AXL3 Antibody; Anti-JTK11 Antibody; Anti-Tyro7 Antibody; Anti-UFO Antibody
Background Information
| Full Name | AXL receptor tyrosine kinase |
| Description | Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo. |
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