| Catalog No. | Size | Price (USD) |
| 10698-MM01-F-25 | 25 Tests | $103.68 |
| 10698-MM01-F-100 | 100 Tests | $222.17 |
General Information
| Product name | Anti-B7-1/CD80 Antibody (FITC), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human B7-1/CD80 |
| Immunogen | Recombinant Human CD80 / B7-1 Protein (Catalog#10698-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD80 / B7-1 (rh CD80 / B7-1; Catalog#10698-H08H; NP_005182.1; Met 1-Asn 242) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| Source | Monoclonal Mouse IgG1 Clone #01 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 10 μl/Test, 0.1 mg/ml |
| Conjugate | FITC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-B7 Antibody; Anti-B7-1 Antibody; Anti-B7.1 Antibody; Anti-BB1 Antibody; Anti-CD28LG Antibody; Anti-CD28LG1 Antibody; Anti-LAB7 Antibody
Image / Experimental Information
| Image 1 Description | Profile of anti-B7-1 (CD80) reactivity on U937 cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with 20 μg of human IgG/10 6 cells for 1 hour at 4 ℃ prior to staining, washed, then stained with FITC Mouse anti-B7-1 (CD80). |
| Image 1 Alt Text | Human CD80/B7-1 Flow Cytometry (FC) 2637 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD80 molecule |
| Description | The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
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| References |
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title: Discovery of an theranostic functional mAb for visualizing the sensitivity and effectiveness of PD-L1 checkpoint therapy.
authors: Jin Wang; Yanchen Li; ...; Yuanyuan Shan
journal: Bioorganic chemistry
date: 2024-11-22
pmid: 39603072
doi: 10.1016/j.bioorg.2024.107992
cited_by_count: 0
techniques: MTT Assay
bioz_score: 92
title: Separation, purification, structure characterization, and immune activity of a polysaccharide from Alocasia cucullata obtained by freeze-thaw treatment.
authors: Huxuan Gong; Xiao Tan; ...; Shian Zhong
journal: International Journal of Biological Macromolecules
date: 2024-11-08
pmid: 39521204
doi: 10.1016/j.ijbiomac.2024.137232
cited_by_count: 134
techniques: Enzyme-linked Immunosorbent Assay
bioz_score: 92
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