| Catalog No. | Size | Price (USD) |
| 11188-T24-50 | 50 µL | $147.96 |
| 11188-T24-100 | 100 µL | $251.64 |
| 11188-T24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-B7-H3 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human B7-H3 |
| Immunogen | Recombinant Human B7-H3/CD276 Protein (Catalog#11188-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human B7-H3/CD276 (rh B7-H3/CD276; Catalog#11188-H08H; Q5ZPR3-1; Met1-Thr461). B7-H3/CD276 specific IgG was purified by Human B7-H3/CD276 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-B7-H3 Antibody; Anti-B7H3 Antibody; Anti-B7RP-2 Antibody; Anti-PSEC0249 Antibody; Anti-UNQ309/PRO352 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human B7H3 in human ovarian cancer with rabbit polyclonal antibody at 1:5000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human B7-H3/CD276 Immunohistochemistry(IHC) 18037 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human B7H3 in human ovarian cancer with rabbit polyclonal antibody at 1:5000 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human B7-H3/CD276 Immunohistochemistry(IHC) 18038 |
| Image 2 URL | Source image |
Background Information
| Full Name | CD276 molecule |
| Description | B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. |
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| References |
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title: Targeting CD276: a promising strategy for CAR-NK cell immunotherapy in human oral tongue squamous cell carcinoma.
authors: Shiyuan Liu; Tian Guan; ...; Xianjun Zhang
journal: BMC Cancer
date: 2025-04-02
pmid: 40169956
cited_by_count: 2
techniques: CCK-8 Assay; Comparison; Control; Expressing; Flow Cytometry; Fluorescence; Immunohistochemistry; Incubation; Lysis; Membrane; Negative Control
bioz_score: 93
title: Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing
authors: Jenny Mattsson; Ludvig Ekdahl; ...; Björn Nilsson
journal: Nature Communications
date: 2021-02-24
pmid: 33627649
doi: 10.1038/s41467-021-21518-4
pmcid: 7904777
cited_by_count: 3
techniques: Produced; Recombinant
bioz_score: 93
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