| Catalog No. | Size | Price (USD) |
| 10890-R211-50 | 50 µL | $177.58 |
| 10890-R211-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-BAMBI Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human BAMBI |
| Immunogen | Recombinant Human BAMBI / NMA Protein (Catalog#10890-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human BAMBI / NMA (rh BAMBI / NMA; Catalog#10890-H08H; NP_036474.1; Met 1-Ala 152). |
| Source | Monoclonal Rabbit IgG Clone #211 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-NMA Antibody
Background Information
| Full Name | BMP and activin membrane-bound inhibitor |
| Description | BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis. |
| References |
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