| Catalog No. | Size | Price (USD) |
| 100787-T02-50 | 50 µL | $147.96 |
| 100787-T02-100 | 100 µL | $251.64 |
| 100787-T02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-BAX Antibody, Rabbit Polyclonal |
| Validated applications | ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human BAX |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human BAX |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human BAX, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BCL2L4 Antibody
Image / Experimental Information
| Image 1 Description | Immunofluorescence staining of BAX in HeLa cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-human BAX polyclonal antibody (1:1000) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cytoplasm and nucleus. |
| Image 1 Alt Text | Human BAX Immunohistochemistry(IHC) 3079 |
| Image 1 URL | Source image |
Background Information
| Full Name | BCL2-associated X protein |
| Description | BCL2 associated X (BAX) is traditionally thought to be regulated by anti-apoptotic BCL-2 family members. BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix alpha5 from alpha6 - the 'latch' from the 'core' domain - among other conformational changes. BCL-2-associated X (BAX) protein acts as a gatekeeper in regulating mitochondria-dependent apoptosis. Under cellular stress, BAX becomes activated and transforms into a lethal oligomer that causes mitochondrial outer membrane permeabilization (MOMP). |
| Related Pathways |
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title: Protective Effect of Rifampicin Loaded by HPMA-PLA Nanopolymer on Macrophages Infected with Mycobacterium Tuberculosis
authors: Guoping Yang; Guofu Wang; ...; Lixian Wu
journal: Computational and mathematical methods in medicine
date: 2022-01-04
pmid: 35027942
doi: 10.1155/2022/5784283
pmcid: 8752210
cited_by_count: 1
techniques: Electrochemiluminescence; Expressing; Incubation; Membrane; Saline; Software
bioz_score: 90
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