Recombinant Human BCL2L11 / Bim Protein (Catalog#13816-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human BCL2L11 / Bim (rh BCL2L11 / Bim; Catalog#13816-H07E; NP_006529.1; Ala2-Arg120). BCL2L11 / Bim specific IgG was purified by Human BCL2L11 / Bim affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
Related Pathways
AKT Signaling Pathway
MAPK-Erk Pathway
References
Day Catherine L. et al., 2004, Biochem J. 377 (3): 597-605.
Murray S. et al., 2001, Cytogenet Cell Genet. 92 (3-4): 353.
Hsu SY. et al., 1998,Mol Endocrinol. 12 (9): 1432-40.