Anti-Bim Antibody, Rabbit Polyclonal sinobiological 13816-T16

$143.00
In stock
SKU
13816-T16
Catalog No.SizePrice (USD)
13816-T16-5050 µL$147.96
13816-T16-100100 µL$251.64
13816-T16-200200 µL$355.32

General Information

Product nameAnti-Bim Antibody, Rabbit Polyclonal
Validated applicationsELISA (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman Bim
ImmunogenRecombinant Human BCL2L11 / Bim Protein (Catalog#13816-H07E)
PreparationProduced in rabbits immunized with purified, recombinant Human BCL2L11 / Bim (rh BCL2L11 / Bim; Catalog#13816-H07E; NP_006529.1; Ala2-Arg120). BCL2L11 / Bim specific IgG was purified by Human BCL2L11 / Bim affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-BAM Antibody; Anti-BIM Antibody; Anti-BimEL Antibody; Anti-BimL Antibody; Anti-BimS Antibody; Anti-BOD Antibody

Background Information

Full NameBCL2-like 11 (apoptosis facilitator)
DescriptionBCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
Related Pathways
  • AKT Signaling Pathway
  • MAPK-Erk Pathway
References
  1. Day Catherine L. et al., 2004, Biochem J. 377 (3): 597-605.
  2. Murray S. et al., 2001, Cytogenet Cell Genet. 92 (3-4): 353.
  3. Hsu SY. et al., 1998,Mol Endocrinol. 12 (9): 1432-40.

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