Anti-BMF Antibody, Rabbit Polyclonal sinobiological 13639-T16

$143.00
In stock
SKU
13639-T16
Catalog No.SizePrice (USD)
13639-T16-5050 µL$147.96
13639-T16-100100 µL$251.64
13639-T16-200200 µL$355.32

General Information

Product nameAnti-BMF Antibody, Rabbit Polyclonal
Validated applicationsELISA (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman BMF
ImmunogenRecombinant Human BMF / Bcl2 modifying factor protein (Catalog#13639-H07E)
PreparationProduced in rabbits immunized with purified, recombinant Human BMF / Bcl2 modifying factor (rh BMF / Bcl2 modifying factor; Catalog#13639-H07E; Q96LC9-1; Met1-Arg184). BMF / Bcl2 modifying factor specific IgG was purified by Human BMF / Bcl2 modifying factor affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-FLJ00065 Antibody

Background Information

Full NameBcl2 modifying factor
DescriptionBMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BMF contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. BMF is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Related Pathways
  • Autophagy Pathway
References
  1. Hattori A, et al. (2001) Characterization of long cDNA clones from human adult spleen. DNA Res. 7(6):357-66.
  2. Day Catherine L, et al. (2004) Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem J. 377(Pt 3):597-605.
  3. Puthalakath H, et al. (2001) Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science. 293(5536):1829-32.

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