| Catalog No. | Size | Price (USD) |
| 11199-T26-50 | 50 µL | $147.96 |
| 11199-T26-100 | 100 µL | $251.64 |
| 11199-T26-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-c-Abl/ABL1 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human c-Abl/ABL1 |
| Immunogen | Recombinant Human c-Abl / ABL1 Protein (Catalog#11199-H09B) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human c-Abl / ABL1 (rh c-Abl / ABL1; Catalog#11199-H09B; NP_009297.2; Pro137-Ser554). c-Abl / ABL1 specific IgG was purified by Human c-Abl / ABL1 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ABL Antibody; Anti-BCR-ABL Antibody; Anti-bcr/abl Antibody; Anti-c-ABL Antibody; Anti-c-ABL1 Antibody; Anti-CHDSKM Antibody; Anti-JTK7 Antibody; Anti-p150 Antibody; Anti-v-abl Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human ABL1 in human breast carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human c-Abl / ABL1 Immunohistochemistry(IHC) 15714 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human ABL1 in human breast carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| Image 2 Alt Text | Human c-Abl / ABL1 Immunofluorescence(IF) 15715 |
| Image 2 URL | Source image |
Background Information
| Full Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
| Description | c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia. |
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| References |
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title: Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders
authors: Jinhwa Lee; Suyeon Jo; ...; Seung Mook Lim
date: 2026-01-27
cited_by_count: 0
techniques: Activity Assay; Incubation; Kinase Assay; Recombinant
bioz_score: 94
title: Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
authors: Jinhwa Lee; Suyeon Jo; ...; Mingzhu Fan
date: 2020-06-02
cited_by_count: 0
techniques: Activity Assay; Incubation; Kinase Assay; Recombinant
bioz_score: 94
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