| Catalog No. | Size | Price (USD) |
| 200445-T44-50 | 50 µL | $147.96 |
| 200445-T44-100 | 100 µL | $251.64 |
| 200445-T44-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Argininosuccinate lyase Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), IHC-P (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Argininosuccinate lyase |
| Immunogen | E. coli-derived Human Argininosuccinate lyase fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human Argininosuccinate lyase fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ASAL Antibody
Image / Experimental Information
| Image 1 Description | Anti-ASL rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: HepG2 Whole Cell Lysate Lane C: HEK293 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:52 kDa Observed band size:52 kDa |
| Image 1 Alt Text | Human Argininosuccinate lyase Western blot (WB) 28588 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-ASL rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: HepG2 Whole Cell Lysate Lane C: HEK293 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:52 kDa Observed band size:52 kDa |
| Image 2 Alt Text | Human Argininosuccinate lyase Immunohistochemistry(IHC) 28589 |
| Image 2 URL | Source image |
| Image 3 Description | Anti-ASL rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: HepG2 Whole Cell Lysate Lane C: HEK293 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:52 kDa Observed band size:52 kDa |
| Image 3 Alt Text | Human Argininosuccinate lyase Immunohistochemistry(IHC) 28590 |
| Image 3 URL | Source image |
| Image 4 Description | Anti-ASL rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: HepG2 Whole Cell Lysate Lane C: HEK293 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:52 kDa Observed band size:52 kDa |
| Image 4 Alt Text | Human Argininosuccinate lyase Immunoprecipitation(IP) 28591 |
| Image 4 URL | Source image |
Background Information
| Full Name | argininosuccinate lyase |
| Description | The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established role in numerous physiological and pathological processes, but the specific cellular sources of NO in disease pathogenesis remain unclear, preventing the implementation of NO-related therapy. Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate for NO generation by nitric oxide synthase (NOS) isoforms. Induction of endogenous NO production by enterocytes with supplements that upregulate ASL expression and complement its substrates results in improved epithelial integrity and alleviation of colitis and of inflammation-associated colon cancer. |
title: Colorectal cancer cell-derived exosomes induce metabolic reprogramming of cancer-associated fibroblasts to promote colorectal cancer growth.
authors: Guopeng Pan; Zexiong Cheng; ...; Rui Wang
journal: Discover oncology
date: 2025-11-24
pmid: 41284138
cited_by_count: 0
techniques: Bicinchoninic Acid Protein Assay; Incubation; Nucleic Acid Electrophoresis; Protease Inhibitor; Western Blot
bioz_score: 93
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