| Catalog No. | Size | Price (USD) |
| 10915-MM03-1 | 1 mL | $1,377.43 |
| 10915-MM03-20 | 20 µL | $88.87 |
| 10915-MM03-50 | 50 µL | $147.96 |
| 10915-MM03-100 | 100 µL | $251.64 |
| 10915-MM03-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Cadherin-16 Antibody, Mouse Monoclonal |
| Validated applications | ELISA(Cap) (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Cadherin-16 |
| Immunogen | Recombinant Human KSP-Cadherin / Cadherin-16 Protein (Catalog#10915-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human KSP-Cadherin / Cadherin-16 (rh KSP-Cadherin / Cadherin-16; Catalog#10915-H08H; NP_004053.1; Met1-Ala786). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #03 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-UNQ695/PRO1340 Antibody
Background Information
| Full Name | cadherin 16 |
| Description | KSP-Cadherin/Cadherin-16 is a member of the cadherin superfamily, calcium-dependent, membrane-associated glycoproteins. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. KSP-Cadherin/Cadherin-16 can be detected at later stages of tubulogenesis during human renal development and in the distal tubules of adult kidneys, no expression was found by immunohistochemistry or Western blot analysis in RCC tumour tissues and several RCC cell lines. However, despite the lack of protein expression, mRNA synthesis of KSP-Cadherin/Cadherin-16 could be detected by reverse transcriptase-polymerase chain reaction analysis in all RCC tissues and most of the RCC cell lines studied, although at a reduced level. The loss of KSP-Cadherin/Cadherin-16 protein was only observed in the malignant part of the tumour kidneys, whereas in the normal part of the affected kidneys KSP-Cadherin/Cadherin-16 expression was clearly detected. These results indicate a downregulation of Ksp-cadherin in RCC and suggest a role for this cell adhesion molecule in tumour suppression. |
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