| Catalog No. | Size | Price (USD) |
| 11360-R032-50 | 50 µL | $177.58 |
| 11360-R032-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-Cadherin-17 Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Cadherin-17 No cross-reactivity in ELISA with Human Cad8 Human E-Cad Human Cad5 |
| Immunogen | Recombinant Human Cadherin-17 / LI-cadherin / CDH17 protein (Catalog#11360-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human Cadherin-17 / LI-cadherin / CDH17 (rh Cadherin-17 / LI-cadherin / CDH17; Catalog#11360-H08H; Q12864-1; Met1-Met787). |
| Source | Monoclonal Rabbit IgG Clone #032 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-cadherin Antibody; Anti-CDH16 Antibody; Anti-HPT-1 Antibody; Anti-HPT1 Antibody
Background Information
| Full Name | cadherin 17, LI cadherin (liver-intestine) |
| Description | Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system. |
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