| Catalog No. | Size | Price (USD) |
| 11783-RP02-50 | 50 µL | $147.96 |
| 11783-RP02-100 | 100 µL | $251.64 |
| 11783-RP02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CALML5 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CALML5 |
| Immunogen | Recombinant Human CALML5 protein (Catalog#11783-H20E) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human CALML5 (rh CALML5; Catalog#11783-H20E; AAH39172.1; Met 1-Glu 146). CALML5 specific IgG was purified by Human CALML5 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CLSP Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CALML5 in human skin (from donor 2) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium. |
| Image 1 Alt Text | Human CALML5 Immunohistochemistry(IHC) 4608 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CALML5 in human skin (from donor 2) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium. |
| Image 2 Alt Text | Human CALML5 Immunohistochemistry(IHC) 4609 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human CALML5 in human skin (from donor 2) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium. |
| Image 3 Alt Text | Human CALML5 Immunohistochemistry(IHC) 4610 |
| Image 3 URL | Source image |
Background Information
| Full Name | calmodulin like 5 |
| Description | Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains fourEF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily and a component of epithelial tight junction. CAR functions as a primary receptor for coxsackievirus B and adenovirus (Ad) infection. CALML5 / CLSP is closely related to CAR. The structure and dynamics of human calmodulin-like skin protein CALML5 / CLSP have been characterized by NMR spectroscopy. The mobility of CALML5 / CLSP has been found to be different for the N-terminal and C-terminal domains. The N-terminal domain is characterized by four stable helices, which experience large fluctuations. This is shown to be due to mutations in the hydrophobic core. The overall N-terminal domain behavior is similar both in the full-length protein and in the isolated domain. |
| Related Pathways |
|
| References |
|
-1ug-skin(from-donor-2).png){kind=link}
-1ug-skin(from-donor-1).png){kind=link}
-1ug-mammary-adenocarcinoma.png){kind=link}