| Catalog No. | Size | Price (USD) |
| 10107-R053-P-25 | 25 Tests | $162.92 |
| 10107-R053-P-100 | 100 Tests | $325.84 |
General Information
| Product name | Recombinant Anti-Carbonic Anhydrase IX/CA9 Antibody (PE), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Carbonic Anhydrase IX/CA9 |
| Immunogen | Recombinant Human Carbonic Anhydrase IX/CA9 Protein (Catalog#10107-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human Carbonic Anhydrase IX/CA9 (rh Carbonic Anhydrase IX/CA9; Catalog#10107-H08H; NP_001207.2; Met1-Asp414) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Source | Monoclonal Rabbit IgG Clone #053 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | PE |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-CAIX Antibody; Anti-G250 Antibody; Anti-MN Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Human CAIX expression on Hela cells. Cells were stained with PE-conjugated anti-Human CAIX. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Human Carbonic Anhydrase IX/CA9 Flow Cytometry (FC) 18329 |
| Image 1 URL | Source image |
Background Information
| Full Name | carbonic anhydrase IX |
| Description | Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers. |
| Research Areas |
|
| Tags |
|
| References |
|
