| Catalog No. | Size | Price (USD) |
| 10458-R004-50 | 50 µL | $177.58 |
| 10458-R004-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-Carbonic Anhydrase XIV/CA14 Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Carbonic Anhydrase XIV/CA14 No cross-reactivity in ELISA with Human CAIX / CA9 Human CA10 / CARPX Human CA12 / CAXII Mouse CA14 / Car14 |
| Immunogen | Recombinant Human CA14 protein (Catalog#10458-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human CA14 / Car14 extracellular domain (rh CA14; Catalog#10458-H08H; NP_036245.1; Met 1-Met 290). |
| Source | Monoclonal Rabbit IgG Clone #004 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CAXiV Antibody; Anti-UNQ690/PRO1335 Antibody
Image / Experimental Information
| Image 1 Description | Anti-CA14 rabbit monoclonal antibody at 1:500 dilution Lane A: Jurkat Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:38 kDa Observed band size:34 kDa |
| Image 1 Alt Text | Human Carbonic Anhydrase XIV Western blot (WB) 16046 |
| Image 1 URL | Source image |
Background Information
| Full Name | carbonic anhydrase XIV |
| Description | The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. CAXIV is a member of CA family that showed an overall similarity of 29–46% to other active CA isozymes. The highest percentage similarity was with a transmembrane CA isoform, CAXII. The CAXIV was found high concentrations in human heart, brain, liver, and skeletal muscle but lower in the colon, small intestine, urinary bladder, and kidney. No CAXIV mRNA was seen in the salivary gland and pancreas. CAXIV is a likely candidate for the extracellular CA postulated to have an important role in modulating excitatory synaptic transmission in brain. |
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