| Catalog No. | Size | Price (USD) |
| 10504-RP02-50 | 50 µL | $147.96 |
| 10504-RP02-100 | 100 µL | $251.64 |
| 10504-RP02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Carboxypeptidase A Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), IHC-P (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Carboxypeptidase A |
| Immunogen | Recombinant Human Carboxypeptidase A1 / CPA1 protein (Catalog#10504-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human Carboxypeptidase A1 / CPA1 (rh Carboxypeptidase A1 / CPA1; Catalog#10504-H08H; NP_001859.1; Met 1-Tyr 419). Carboxypeptidase A1 / CPA1 specific IgG was purified by Human Carboxypeptidase A1 / CPA1 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CPA Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CPA1 in human pancreas with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human Carboxypeptidase A1/CPA1 Immunohistochemistry(IHC) 4372 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CPA1 in human pancreas with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). |
| Image 2 Alt Text | Human Carboxypeptidase A1/CPA1 Immunoprecipitation(IP) 7997 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human CPA1 in human pancreas with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). |
| Image 3 Alt Text | Human Carboxypeptidase A1/CPA1 Western blot (WB) 13242 |
| Image 3 URL | Source image |
Background Information
| Full Name | carboxypeptidase A1 (pancreatic) |
| Description | Carboxypeptidase A1 （CPA1）is secreted as a pancreatic procarboxypeptidase, and cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group, with the preference of residues with aromatic or branched aliphatic side chains. CPA1 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. In contrast to procarboxypeptidase B which was always secreted by the pancreas as a monomer, procarboxypeptidase A occurs as a monomer and/or associated to one or two functionally different proteins, such as zymogen E, and is involved in zymogen inhibition. Three different forms of human pancreatic procarboxypeptidase A have been isolated. |
| References |
|
title: Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
authors: Ling Huang; Ridhdhi Desai; ...; Senthil K. Muthuswamy
journal: Cell Stem Cell
date: 2021-06-03
pmid: 33915081
doi: 10.1016/j.stem.2021.03.022
pmcid: 8202734
cited_by_count: 116
techniques: Activity Assay; Cell Recovery; Colorimetric Assay; Immunofluorescence; Plasmid Preparation; Recombinant; Software; Staining
bioz_score: 90
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