| Catalog No. | Size | Price (USD) |
| 14333-RP01-100 | 100 µL | $147.96 |
| 14333-RP01-200 | 200 µL | $251.64 |
| 14333-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-CARHSP1 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CARHSP1 |
| Immunogen | Recombinant Human CARHSP1 protein (Catalog#14333-H07E) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human CARHSP1 (rh CARHSP1; Catalog#14333-H07E; Q9Y2V2; Met1-Ser147). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CRHSP-24 Antibody; Anti-CRHSP24 Antibody; Anti-CSDC1 Antibody
Background Information
| Full Name | calcium regulated heat stable protein 1, 24kDa |
| Description | CARHSP1 is a biomarker for diabetic complications. Adenovirus-mediated CARHSP1 overexpression and siRNA-mediated knockdown experiments were performed to characterize the role of CARHSP1 in the regulation of gluconeogenic gene expression. CARHSP1 is regulated by nutrient status in the liver and functions at the transcriptional level to negatively regulate gluconeogenic genes, including the glucose-6-phosphatase catalytic subunit (G6Pc) and phosphoenolpyruvate carboxykinase 1 (PEPCK1). In addition, it is found that CARHSP1 can physically interact with peroxisome proliferator-activated receptor-α (PPARα) and inhibit its transcriptional activity. Both pharmacological and genetic ablations of PPARα attenuate the inhibitory effect of CARHSP1 on gluconeogenic gene expression in hepatocytes. |
| References |
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