| Catalog No. | Size | Price (USD) |
| 10516-MM01-20 | 20 µL | $88.87 |
| 10516-MM01-50 | 50 µL | $147.96 |
| 10516-MM01-100 | 100 µL | $251.64 |
| 10516-MM01-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-IL-3R Beta/IL3RB Antibody, Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-3R Beta/IL3RB |
| Immunogen | Recombinant Human CD131 / CSF2RB / IL3RB / IL5RB protein (Catalog#10516-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD131 / CSF2RB / IL3RB / IL5RB (rh CD131 / CSF2RB / IL3RB / IL5RB; Catalog#10516-H08H; NP_000386.1; Met1-Trp443). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #01 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-betaGMR Antibody; Anti-CD131 Antibody; Anti-CDw131 Antibody; Anti-IL3RB Antibody; Anti-IL5RB Antibody; Anti-SMDP5 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Human CSF2RB(CD131) expression on TF-1 cells. Cells were stained with purified anti-Human CSF2RB(CD131), then a PE-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Human CD131/CSF2RB/IL3RB/IL5RB Flow Cytometry (FC) 5199 |
| Image 1 URL | Source image |
Background Information
| Full Name | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
| Description | Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. |
| References |
|
title: Rapid Screen of IL-5/IL-5Rα Blocking Antibodies in the HEK293-IL-5Rα-CSF2RB Transfected Cell Line
authors: Shijie Li; Fei Han; ...; Zhonghu Bai
journal: Biotechnology and Bioprocess Engineering
date: 2023-05-20
doi: 10.1007/s12257-022-0315-2
cited_by_count: 2
techniques: Cell Culture; Expressing; FACS; Lysis; Staining
bioz_score: 91
-MM01-Purified-TF-1.png){kind=link}