| Catalog No. | Size | Price (USD) |
| 201563-T08-50 | 50 µL | $147.96 |
| 201563-T08-100 | 100 µL | $251.64 |
| 201563-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-ARL3 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ARL3 |
| Immunogen | E. coli-derived Human ARL3 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human ARL3 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ARFL3 Antibody; Anti-JBTS35 Antibody; Anti-RP83 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human ARL3 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human ARL3 Immunohistochemistry(IHC) 24157 |
| Image 1 URL | Source image |
Background Information
| Full Name | ADP ribosylation factor like GTPase 3 |
| Description | ADP-ribosylation factor-like3 (ARL3) is a member of the ADP-ribosylation factor family of GTP-binding proteins that plays important role in regulating Ciliary trafficking. It ubiquitously expressed in normal tissues and tumor cell lines. The knockouts reveal binary functions of ARL3-GTP as a key molecule in late-stage photoreceptor ciliogenesis and cargo displacement factor. ARL3 is a key player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms of XLRP. The activity of ARL3 is regulated by a GEF (ARL13b) and a GAP (RP2). In a mouse germline knockout of RP2, ARL3-GTP is abundant as its intrinsic GTPase activity is extremely low. High levels of ARL3-GTP impair binding and trafficking of cargo to the outer segment. Germline knockout of ARL3 is embryonically lethal generating a syndromic ciliopathy-like phenotype. |
| References |
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