| Catalog No. | Size | Price (USD) |
| 201237-T08-50 | 50 µL | $147.96 |
| 201237-T08-100 | 100 µL | $251.64 |
| 201237-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Aromatase/CYP19A1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Aromatase/CYP19A1 |
| Immunogen | E. coli-derived Human Aromatase/CYP19A1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human Aromatase/CYP19A1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ARO Antibody; Anti-ARO1 Antibody; Anti-aromatase Antibody; Anti-CPV1 Antibody; Anti-CYAR Antibody; Anti-CYP19 Antibody; Anti-CYPXIX Antibody; Anti-P-450AROM Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CYP19A1 in human placenta with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Aromatase Immunohistochemistry(IHC) 23898 |
| Image 1 URL | Source image |
Background Information
| Full Name | cytochrome P450, family 19, subfamily A, polypeptide 1 |
| Description | The cytochrome P450 family 19 subfamily A member 1 (CYP19A1) gene, encodes aromatase, a key enzyme in estradiol (E2) synthesis, and is down-regulated during porcine follicular atresia. CYP19A1 gene stimulates E2 release and inhibits cell apoptosis in porcine granulosa cells (GCs). The single nucleotide polymorphisms in CYP19A1 gene may alter aromatase activity and circulating steroid hormone levels in females. High CYP19A1 expression was highly significantly associated with a poor overall, disease-free, and metastasis-free survival in estrogen receptor-positive but not negative breast cancer patients. Estrogen production by the human villous trophoblast is dependent on the biosynthetic enzyme aromatase (CYP19; CYP19A1) and is crucial for successful placental development and pregnancy outcome. |
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