| Catalog No. | Size | Price (USD) |
| 200444-T08-50 | 50 µL | $147.96 |
| 200444-T08-100 | 100 µL | $251.64 |
| 200444-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-ARP2/3 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ARP2/3 |
| Immunogen | E. coli-derived Human ARP2/3 (ARPC1B) fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human ARP2/3 (ARPC1B) fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ARC41 Antibody; Anti-IMD71 Antibody; Anti-p40-ARC Antibody; Anti-p41-ARC Antibody; Anti-PLTEID Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human ARPC1B in human lymph node with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human ARP2/3 Immunohistochemistry(IHC) 25040 |
| Image 1 URL | Source image |
Background Information
| Full Name | actin related protein 2/3 complex, subunit 1B, 41kDa |
| Description | Arpc1b, was earlier found to be down-regulated in an estrogen-induced rat model of spermiation failure. Also, Arpc1b was found to be estrogen responsive through estrogen receptor beta in seminiferous tubule culture. Here, knockdown of Arpc1b by siRNA in adult rat testis led to defects in spermiation caused by failure in TBC formation. Knockdown also compromised BTB integrity and caused polarity defects of mature spermatids. Apart from these effects pertaining to Sertoli cells, Arpc1b reduction perturbed ability of germ cells to enter G2/M phase thus hindering cell division. That Arpc1b, an estrogen responsive gene, is a regulator of spermiation, mature spermatid polarity, BTB integrity and cell division during adult spermatogenesis. Low-expression of ARPC1B is significantly associated with LNM and advanced tumor staging whereas high expression of Cav-1 can be a prognostic indicator for poor prognosis in OSCC patients. Arp2/3 complexes containing ARPC1B and ARPC5L are significantly better at promoting actin assembly than those with ARPC1A and ARPC5, both in cells and in vitro. Branched actin networks induced by complexes containing ARPC1B or ARPC5L are also disassembled ∼2-fold slower than those formed by their counterparts. |
| Related Pathways |
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