Anti-CD19 Antibody (FITC), Mouse Monoclonal sinobiological 11880-MM17-F

$43.00
In stock
SKU
11880-MM17-F
Catalog No.SizePrice (USD)
11880-MM17-F-2525 Tests$44.43
11880-MM17-F-100100 Tests$103.68

General Information

Product nameAnti-CD19 Antibody (FITC), Mouse Monoclonal
Validated applicationsFCM (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CD19
ImmunogenRecombinant Human CD19 Protein (Catalog#11880-H08H)
PreparationThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD19 (rh CD19; Catalog#11880-H08H; P15391-1; Met1-Lys291) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
SourceMonoclonal Mouse IgG1 Clone #17
PurificationProtein A
FormulationPBS solution containing 0.5% BSA and 0.03%ProClin300
Concentration10 μl/Test, 0.1 mg/ml
ConjugateFITC
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Synonyms: Anti-B4 Antibody; Anti-CVID3 Antibody

Image / Experimental Information

Image 1 DescriptionFlow cytometric analysis of Human CD19 expression on human whole blood lymphocytes. Cells were stained with FITC-conjugated anti-Human CD19 and PE-conjugated anti-Human CD3. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
Image 1 Alt TextHuman CD19 Flow Cytometry (FC) 26223
Image 1 URLSource image

Background Information

Full NameCD19 molecule
DescriptionThe cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 19 (CD19) is a member of CD system. CD19 is a cell surface molecule that assembles with the antigen receptor of B-cells. This results in a descent in the threshold for antigen receptor-dependent stimulation. A simplified view holds that the ability of B-cells to respond to the various antigens in a specific and sensitive manner is achieved in the presence of low-affinity antigen receptors. CD19 primarily acts as a B-cell co-receptor in conjunction with CD21 and CD81. The formation of the receptor complex is induced by antigen and CD19, induced by exogenous antigen, has been found cytoplasmic tail phosphorylated and bind to sIg.
Research Areas
  • Cancer Drug Targets
Related Pathways
  • B Cell Receptor Signaling Pathway
Tags
  • Cancer Immunotherapy
  • Immune Checkpoint
  • Immunotherapy
  • Targeted Therapy
References
  1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  4. Carter RH, et al. (1992) CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science. 256 (5053): 105-7.

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authors: Nikolai Kley; Jan Tavernier; Frank Peelman
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techniques: Activity Assay; FACS; Gradient Centrifugation; Isolation; Phospho-proteomics; Purification; Serial Dilution; Software; Staining
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techniques: Blocking Assay; Control; Derivative Assay; Expressing; Flow Cytometry; Generated; Incubation; Marker; Negative Staining
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authors: Meng Wang; Haonan Zheng; ...; Zhiwei Sui
journal: Analytical Chemistry
date: 2025-07-02
pmid: 40600817
doi: 10.1021/acs.analchem.5c01862
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title: Targeted mutant interferon-beta and uses thereof
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date: 2022-02-01
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bioz_score: 93

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