| Catalog No. | Size | Price (USD) |
| 10039-R023-P-25 | 25 Tests | $44.43 |
| 10039-R023-P-100 | 100 Tests | $103.68 |
General Information
| Product name | Recombinant Anti-CD27/TNFRSF7 Antibody (PE), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD27/TNFRSF7 |
| Immunogen | Recombinant Human CD27 / TNFRSF7 protein (Catalog#10039-H03H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant human CD27 (rh CD27; Catalog#10039-H03H; Met 1-Ile 192; NP_001233.1) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Source | Monoclonal Rabbit IgG Clone #023 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Concentration | 10 μl/Test, 0.1 mg/ml |
| Conjugate | PE |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Synonyms: Anti-S152 Antibody; Anti-S152. LPFS2 Antibody; Anti-T14 Antibody; Anti-TNFRSF7 Antibody; Anti-Tp55 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of anti-human CD27 on human whole blood lymphocytes. Human lymphocytes were stained with anti human CD27-R023 (solid line) or rabbit IgG isotype control (dashed line). |
| Image 1 Alt Text | Human CD27/TNFRSF7 Flow Cytometry (FC) 5421 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD27 molecule |
| Description | CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis. |
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| References |
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title: Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques
authors: Xuan He; Abishek Chandrashekar; ...; Dan H. Barouch
journal: Cell
date: 2021-06-01
pmid: 34133941
doi: 10.1016/j.cell.2021.05.040
pmcid: 8166510
cited_by_count: 51
techniques: Binding Assay; Blocking Assay; Enzyme-linked Immunospot; Expressing; Flow Cytometry; Incubation; Infection; Labeling; Plasmid Preparation; Real-time Polymerase Chain Reaction; Recombinant; Software; Staining
bioz_score: 90
