Anti-ATF2 Antibody, Rabbit Polyclonal sinobiological 11599-T52
$243.00
In stock
SKU
11599-T52
| Catalog No. | Size | Price (USD) |
| 11599-T52-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-ATF2 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ATF2 |
| Immunogen | Recombinant Human ATF2 Protein (Catalog#11599-H20B) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human ATF2 (rh ATF2; Catalog#11599-H20B; P15336-1; Met1-Ser505). ATF2 specific IgG was purified by Human ATF2 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CRE-BP1 Antibody; Anti-CREB-2 Antibody; Anti-CREB2 Antibody; Anti-CREBP1 Antibody; Anti-HB16 Antibody; Anti-TREB7 Antibody
Image / Experimental Information
| Image 1 Description | ATF2 was immunoprecipitated using: Lane A:0.5 mg 293 Whole Cell Lysate Lane B:0.5 mg HeLa Whole Cell Lysate 4 µL anti-ATF2 rabbit polyclonal antibody and 60 μg of Immunomagnetic beads Protein A/G. Primary antibody: Anti-ATF2 rabbit polyclonal antibody,at 1:100 dilution Secondary antibody: Clean-Blot IP Detection Reagent (HRP) at 1:1000dilution Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 52 kDa Observed band size :60 kDa |
| Image 1 Alt Text | Human ATF2 Immunoprecipitation(IP) 37063 |
| Image 1 URL | Source image |
| Image 2 Description | ATF2 was immunoprecipitated using: Lane A:0.5 mg 293 Whole Cell Lysate Lane B:0.5 mg HeLa Whole Cell Lysate 4 µL anti-ATF2 rabbit polyclonal antibody and 60 μg of Immunomagnetic beads Protein A/G. Primary antibody: Anti-ATF2 rabbit polyclonal antibody,at 1:100 dilution Secondary antibody: Clean-Blot IP Detection Reagent (HRP) at 1:1000dilution Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 52 kDa Observed band size :60 kDa |
| Image 2 Alt Text | Human ATF2 Western blot (WB) 37062 |
| Image 2 URL | Source image |
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Background Information
| Full Name | activating transcription factor 2 |
| Description | Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. ATF2 has been found to be a target of the JNK signal transduction pathway and mediate adenovirus E1A-inducible transcriptional activation. ATF2 is also been reported playing roles in TGF-β signaling pathway. It has been shown that the transcription factor ATF2 is bound by a hetero-oligomer of Smad3 and Smad4 upon TGF-β stimulation. Studies indicate that ATF-2 plays a central role in TGF-β signaling by acting as a common nuclear target of both Smad and TAK1 pathways. |
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