| Catalog No. | Size | Price (USD) |
| 10774-MM03-F-25 | 25 Tests | $103.68 |
| 10774-MM03-F-100 | 100 Tests | $222.17 |
General Information
| Product name | Anti-CD40/TNFRSF5 Antibody (FITC), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD40/TNFRSF5 |
| Immunogen | Recombinant Human CD40 protein (Catalog#10774-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD40 / TNFRSF5 (rh CD40 / TNFRSF5; Catalog#10774-H08H; NP_001241.1; Met 1-Arg 193) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| Source | Monoclonal Mouse IgG2b Clone #3A4B7 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 10 μl/Test, 0.1 mg/ml |
| Conjugate | FITC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-Bp50 Antibody; Anti-CDW40 Antibody; Anti-p50 Antibody; Anti-TNFRSF5 Antibody
Image / Experimental Information
| Image 1 Description | Profile of CD40 reactivity on Daudi cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with 10 μg of human IgG/10 6 cells for 1 hour at 4℃ prior to staining, washed, then stained with FITC Mouse anti-CD40 (MM03). |
| Image 1 Alt Text | Human CD40/TNFRSF5 Flow Cytometry (FC) 2548 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD40 molecule, TNF receptor superfamily member 5 |
| Description | CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. |
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| References |
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title: Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation and Coagulation
authors: Jung Hwa Park; Jong-Hwa Jang; ...; Yeong-Min Park
journal: Molecular Medicine
date: 2016-07-06
pmid: 27447360
pmcid: 5072405
cited_by_count: 25
techniques: Activation Assay; Cell Culture; Concentration Assay; Control; Cytometry; Enzyme-linked Immunosorbent Assay; Flow Cytometry; Fluorescence; In Vitro; In Vivo; Incubation; Injection; Isolation; Marker; Negative Control; Positive Control; Software; Staining; Western Blot
bioz_score: 90
