| Catalog No. | Size | Price (USD) |
| 10774-MM17-P-25 | 25 Tests | $103.68 |
| 10774-MM17-P-100 | 100 Tests | $222.17 |
General Information
| Product name | Anti-CD40/TNFRSF5 Antibody (PE), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD40/TNFRSF5 |
| Immunogen | Recombinant Human CD40 / TNFRSF5 protein (Catalog#10774-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD40 / TNFRSF5 (rh CD40 / TNFRSF5; Catalog#10774-H08H; NP_001241.1; Met1-Arg193) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Source | Monoclonal Mouse IgG2b Clone #17 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Concentration | 1 μl/Test, 0.1 mg/ml |
| Conjugate | PE |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Synonyms: Anti-Bp50 Antibody; Anti-CDW40 Antibody; Anti-p50 Antibody; Anti-TNFRSF5 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of human CD40 expression on human whole blood lymphocytes. Human whole blood lymphocytes were stained with PE-conjugated anti-Human CD40 and APC-conjugated anti-Human CD19(BD Pharmingen™). The histogram were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Image 1 Alt Text | Human CD40/TNFRSF5 Flow Cytometry (FC) 5259 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD40 molecule, TNF receptor superfamily member 5 |
| Description | CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. |
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| References |
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title: Cell-Based Models of 'Cytokine Release Syndrome' Endorse CD40L and Granulocyte-Macrophage Colony-Stimulating Factor Knockout in Chimeric Antigen Receptor T Cells as Mitigation Strategy.
authors: Ala Dibas; Manuel Rhiel; ...; Toni Cathomen
journal: Cells
date: 2023-11-13
pmid: 37947658
cited_by_count: 4
techniques: Flow Cytometry
bioz_score: 92
