| Catalog No. | Size | Price (USD) |
| 12211-R001-50 | 50 µL | $177.58 |
| 12211-R001-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-CD44 Antibody, Rabbit Monoclonal |
| Validated applications | ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD44 |
| Immunogen | Recombinant Human CD44 protein (Catalog#12211-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD44 (rh CD44; Catalog#12211-H08H; P16070-1; Met1-Pro220). |
| Source | Monoclonal Rabbit IgG Clone #001 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD44R Antibody; Anti-CDW44 Antibody; Anti-CSPG8 Antibody; Anti-ECM-III Antibody; Anti-ECMR-III Antibody; Anti-H-CAM Antibody; Anti-HCELL Antibody; Anti-Hermes-1 Antibody; Anti-HUTCH-1 Antibody; Anti-HUTCH-I Antibody; Anti-IN Antibody; Anti-LHR Antibody; Anti-MC56 Antibody; Anti-MDU2 Antibody; Anti-MDU3 Antibody; Anti-MIC4 Antibody; Anti-PGP-1 Antibody; Anti-Pgp1 Antibody
Image / Experimental Information
| Image 1 Description | Immunofluorescence staining of Human CD44 in Hela cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-Human CD44 monoclonal antibody (1:60) at 37℃ 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cells membrane. |
| Image 1 Alt Text | Human CD44 Immunofluorescence(IF) 2970 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD44 molecule (Indian blood group) |
| Description | CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis. |
| References |
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title: GSK-3 inhibitor induces apoptosis and cell cycle arrest in CD133 + /CD44 + prostate cancer cells through modulation of Notch signaling pathway.
authors: Eda Acikgoz; Berrin Ozdil; ...; Cafer Tas
journal: Molecular Biology Reports
date: 2025-09-11
pmid: 40932535
doi: 10.1007/s11033-025-10977-3
cited_by_count: 0
techniques: Annexin V Assay; Binding Assay; Cell Culture; Incubation; Membrane; Suspension
bioz_score: 93
title: Selective fluorescent probe for aldehyde dehydrogenase
authors: Thomas Edward Bearrood; Chelsea Diane Anorma; Jefferson Chan
date: 2022-08-09
cited_by_count: 0
techniques: Fluorescence; Imaging; Spectroscopy; Staining
bioz_score: 93
title: Labeling Cell Surface Receptors with Ligand.BirA* Bispecifics
authors: Mays Alwash; Jean Gariépy
journal: ACS pharmacology & translational science
date: 2022-02-01
doi: 10.1021/acsptsci.1c00192
pmcid: 9890520
cited_by_count: 0
techniques: Derivative Assay; Expressing; Immunoprecipitation; Labeling; Marker; Multiple Displacement Amplification; SDS Page; Western Blot
bioz_score: 93
