| Catalog No. | Size | Price (USD) |
| 10086-MM05-F-25 | 25 Tests | $44.43 |
| 10086-MM05-F-100 | 100 Tests | $103.68 |
General Information
| Product name | Anti-CD45 Antibody (FITC), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD45 |
| Immunogen | Recombinant Human CD45 protein (Catalog#10086-H02H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD45 (rh CD45; Catalog#10086-H02H; NP_563578.2; Met1-Lys416) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| Source | Monoclonal Mouse IgG1 Clone #05 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 10 μl/Test, 0.1 mg/ml |
| Conjugate | FITC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-B220 Antibody; Anti-CD45 Antibody; Anti-CD45R Antibody; Anti-GP180 Antibody; Anti-IMD105 Antibody; Anti-L-CA Antibody; Anti-LCA Antibody; Anti-LY5 Antibody; Anti-T200 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Human CD45 expression on human whole blood lymphocytes. Cells were stained with FITC-conjugated anti-Human CD45. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Image 1 Alt Text | Human CD45 Flow Cytometry (FC) 26137 |
| Image 1 URL | Source image |
Background Information
| Full Name | protein tyrosine phosphatase, receptor type, C |
| Description | The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases. |
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| References |
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title: Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis-Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation.
authors: Long-Bo Yu; Peng Wang; ...; Cai-Ping Tan
journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
date: 2025-11-26
pmid: 41298247
cited_by_count: 1
techniques: Blocking Assay; Lysis; Microscopy
bioz_score: 93
title: Single-cell RNA sequencing of endometrium uncovers dynamic characteristics and dysregulation of perivascular CD9 + SUSD2 + cells in thin endometrium
authors: Binfa Liang; Lingbin Qi; ...; Xian Chen
journal: Stem Cell Research & Therapy
date: 2025-09-26
cited_by_count: 0
techniques: Blocking Assay; Control; Derivative Assay; Expressing; Flow Cytometry; Generated; Incubation; Marker; Negative Staining
bioz_score: 93
title: Identifying the target, mechanism, and agonist of α-ketoglutaric acid in delaying mesenchymal stem cell senescence.
authors: Zhao Cui; Jiameng Li; ...; Peng Chen
journal: Cell Reports
date: 2025-06-25
pmid: 40570373
doi: 10.1016/j.celrep.2025.115917
cited_by_count: 2
bioz_score: 93
title: Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions
authors: Jun Song; Meiqi Li; ...; Jianyong Xu
journal: Stem Cell Research & Therapy
date: 2025-02-04
pmid: 39901307
doi: 10.1186/s13287-025-04183-y
pmcid: 11792338
cited_by_count: 2
bioz_score: 90
title: The novel target, mechanism and agonist of α-Ketoglutaric acid in delaying mesenchymal stem cell senescence
authors: Peng Chen; Zhao Cui; ...; Hongjun Yang
journal: Europe PMC
date: 2024-09-25
doi: 10.21203/rs.3.rs-5000966
cited_by_count: 0
techniques: Binding Assay; Flow Cytometry; Microscopy; Plasmid Preparation; Recombinant; Staining; Synthesized; shRNA
bioz_score: 93
title: Effects of triclosan exposure on stem cells from human exfoliated deciduous teeth (SHED) fate.
authors: Shiwen Deng; Caifeng Li; ...; Peng Chen
journal: The Science of The Total Environment
date: 2023-11-15
pmid: 37709070
doi: 10.1016/j.scitotenv.2023.167053
cited_by_count: 6
techniques: Flow Cytometry; Staining
bioz_score: 93
title: Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement
authors: Zhidi Pan; Jie Chen; ...; Jianwei Zhu
journal: Acta Pharmaceutica Sinica. B
date: 2021-11-03
doi: 10.1016/j.apsb.2021.10.028
pmcid: 9279644
cited_by_count: 17
techniques: Incubation; Labeling; Lysis
bioz_score: 93
title: Enhancing the antitumor activity of an engineered TRAIL-coated oncolytic adenovirus for treating acute myeloid leukemia
authors: Zixuan Wang; Wenmo Liu; ...; Xianghui Yu
journal: Signal transduction and targeted therapy
date: 2020-04-24
pmid: 32327638
doi: 10.1038/s41392-020-0135-9
pmcid: 7181830
cited_by_count: 14
techniques: Cell Culture; Expressing; Flow Cytometry; Injection; Real-time Polymerase Chain Reaction; Recombinant; Staining; Transplantation Assay; Western Blot
bioz_score: 93
title: Generation of a monoclonal antibody recognizing the heavily glycosylated CD45 protein and its application on identifying circulating tumor cells
authors: Weikai Zhang; Zhitao Li; ...; Jeffrey Chalmers
journal: PLoS ONE
date: 2018-02-09
pmid: 29425242
doi: 10.1371/journal.pone.0192506
pmcid: 5806877
cited_by_count: 3
techniques: Binding Assay; Derivative Assay; Enzyme-linked Immunosorbent Assay; Expressing; Flow Cytometry; Isolation; Labeling; Marker; Molecular Weight; Negative Control; Plasmid Preparation; Purification; Recombinant; SDS Page; Software; Staining
bioz_score: 93
title: Peptide-based isolation of circulating tumor cells by magnetic nanoparticles.
authors: Linling Bai; Yimeng Du; ...; Chen Wang
journal: Journal of Materials Chemistry B
date: 2014-01-01
pmid: 32261739
doi: 10.1039/c4tb00456f
cited_by_count: 81
techniques: Cell Culture; Recombinant
bioz_score: 93
