| Catalog No. | Size | Price (USD) |
| 11091-RP02-50 | 50 µL | $147.96 |
| 11091-RP02-100 | 100 µL | $251.64 |
| 11091-RP02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CD74 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), IHC-P (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD74 |
| Immunogen | Recombinant Human CD74 protein (Catalog#11091-H07H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human CD74 extracellular domain (rh CD74; Catalog#11091-H07H; NP_004346.1; Gln 73-Met 232). CD74 specific IgG was purified by human CD74 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CLIP Antibody; Anti-DHLAG Antibody; Anti-HLADG Antibody; Anti-Ia-GAMMA Antibody; Anti-II Antibody; Anti-p33 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CD74 in human rectal cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human CD74 Immunohistochemistry(IHC) 4470 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CD74 in human rectal cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| Image 2 Alt Text | Human CD74 Immunohistochemistry(IHC) 4471 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human CD74 in human rectal cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| Image 3 Alt Text | Human CD74 Immunohistochemistry(IHC) 4473 |
| Image 3 URL | Source image |
| Image 4 Description | Immunochemical staining of human CD74 in human rectal cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| Image 4 Alt Text | Human CD74 Immunoprecipitation(IP) 8048 |
| Image 4 URL | Source image |
| Image 5 Description | Immunochemical staining of human CD74 in human rectal cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| Image 5 Alt Text | Human CD74 Western blot (WB) 13338 |
| Image 5 URL | Source image |
Background Information
| Full Name | CD74 molecule, major histocompatibility complex, class II invariant chain |
| Description | The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD74, also known as HLA class2 histocompatibility antigen gamma chain and HLA-DR antigens-associated invariant chain, is a polypeptide involved in the formation and transport of MHC class2 protein. CD74 is expressed by B cells, macrophages, and Reed-Sternberg cells. When MHC class 2 protein was in the rough ER, its peptide-binding cleft was blocked by CD74 to prevent it from interacting with the endogenous peptides. CD74 also serves to facilitate MHC class2's export from ER. |
| References |
|
title: Predictive value of CXCL10 for the occurrence of immune-related adverse events in patient with renal cell carcinoma.
authors: Yuji Miura; Takanobu Motoshima; ...; Yoshihiro Komohara
journal: Microbiology and immunology
date: 2023-10-20
pmid: 36975091
doi: 10.1111/1348-0421.13067
cited_by_count: 9
techniques: Enzyme-linked Immunosorbent Assay; Incubation; Purification; Recombinant; Saline
bioz_score: 91
title: Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs
authors: Dzmitry Sinitski; Katrin Gruner; ...; Jürgen Bernhagen
journal: Journal of Biological Chemistry
date: 2019-12-06
doi: 10.1074/jbc.ra119.009716
cited_by_count: 1
techniques: Binding Assay; Incubation
bioz_score: 91
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