| Catalog No. | Size | Price (USD) |
| 10980-MM22-50 | 50 µL | $147.96 |
| 10980-MM22-100 | 100 µL | $251.64 |
| 10980-MM22-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CD8 alpha Antibody, Mouse Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD8 alpha No cross-reactivity in ELISA with Human cell lysate (293 cell line) |
| Immunogen | Recombinant Human CD8a / Lyt2 protein (Catalog#10980-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD8a / Lyt2 (rh CD8a / Lyt2; Catalog#10980-H08H; NP_001759.3; Met1-Asp182). The IgG fraction of the cell culture supernatant was purified by Protein A affinity. |
| Source | Monoclonal Mouse IgG1 Clone #22 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD8 Antibody; Anti-CD8alpha Antibody; Anti-IMD116 Antibody; Anti-Leu2 Antibody; Anti-MAL Antibody; Anti-p32 Antibody
Background Information
| Full Name | CD8a molecule |
| Description | T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. |
