| Catalog No. | Size | Price (USD) |
| 10699-MM06-50 | 50 µL | $147.96 |
| 10699-MM06-100 | 100 µL | $251.64 |
| 10699-MM06-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-B7-2/CD86 Antibody, Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human B7-2/CD86 |
| Immunogen | Recombinant Human CD86 / B7-2 protein (Catalog#10699-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD86 / B7-2 (rh CD86 / B7-2; Catalog#10699-H08H; NP_008820.2; Met1-His239). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #06 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-B7-2 Antibody; Anti-B7.2 Antibody; Anti-B70 Antibody; Anti-CD28LG2 Antibody; Anti-LAB72 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Human B7-2(CD86) expression on Daudi cells. Cells were stained with purified anti-Human B7-2(CD86), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Human CD86/B7-2 Flow Cytometry (FC) 5339 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD86 antigen |
| Description | CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy. |
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| References |
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title: Engineered Microglia‐Exosomes Coated Highly Twisting AIE Photothermal Agents to Efficiently Cross Blood‐Brain‐Barrier for Mild Photothermal‐Immune Checkpoint Blockade Therapy in Glioblastoma
authors: Xun Lin; Zhihong Sun; ...; Wenbin Deng
journal: Advanced Functional Materials
date: 2023-12-29
doi: 10.1002/adfm.202310237
cited_by_count: 17
techniques: CCK-8 Assay; Clone Assay; DNA Sequencing; Expressing; Labeling; Luciferase; Modification; Over Expression; Plasmid Preparation; Produced; Recombinant; Transfection
bioz_score: 91
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