| Catalog No. | Size | Price (USD) |
| 12589-MM04-1 | 1 mL | $1,377.43 |
| 12589-MM04-20 | 20 µL | $88.87 |
| 12589-MM04-50 | 50 µL | $147.96 |
| 12589-MM04-100 | 100 µL | $251.64 |
| 12589-MM04-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-C1qR1/CD93 Antibody, Mouse Monoclonal |
| Validated applications | ELISA(Cap) (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human C1qR1/CD93 |
| Immunogen | Recombinant Human CD93/C1qR Protein (Catalog#12589-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD93/C1qR (rh CD93/C1qR; Catalog#12589-H08H; Q9NPY3; Met1-Lys580). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #04 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-C1qR(P) Antibody; Anti-C1QR1 Antibody; Anti-C1qRP Antibody; Anti-CDw93 Antibody; Anti-dJ737E23.1 Antibody; Anti-ECSM3 Antibody; Anti-MXRA4 Antibody
Background Information
| Full Name | CD93 molecule |
| Description | CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches. |
| References |
|
title: Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy
authors: Yi Sun; Wei Chen; ...; Yuwen Zhu
journal: Science translational medicine
date: 2021-07-28
pmid: 34321321
doi: 10.1126/scitranslmed.abc8922
pmcid: 8749958
cited_by_count: 70
techniques: Affinity Column; Binding Assay; Blocking Assay; Cell Culture; Construct; Enzyme-linked Immunosorbent Assay; Expressing; Flow Cytometry; Fluorescence; Generated; In Vivo; Incubation; Isolation; Microscale Thermophoresis; Positive Control; Purification; RNA Sequencing Assay; Real-time Polymerase Chain Reaction; Staining; Transfection; Western Blot
bioz_score: 90
