| Catalog No. | Size | Price (USD) |
| 101573-T10-50 | 50 µL | $147.96 |
| 101573-T10-100 | 100 µL | $251.64 |
| 101573-T10-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-ATR Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human, Mouse |
| Specificity | Human, Mouse |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human ATR |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human ATR, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FCTCS Antibody; Anti-FRP1 Antibody; Anti-MEC1 Antibody; Anti-SCKL Antibody; Anti-SCKL1 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining ATR in human testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human ATR Immunohistochemistry(IHC) 20317 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining ATR in human testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human ATR Immunohistochemistry(IHC) 20318 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining ATR in human testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections. |
| Image 3 Alt Text | Human ATR Immunohistochemistry(IHC) 20319 |
| Image 3 URL | Source image |
| Image 4 Description | Immunochemical staining ATR in human testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections. |
| Image 4 Alt Text | Human ATR Immunofluorescence(IF) 20320 |
| Image 4 URL | Source image |
Background Information
| Description | ATR is a serine/threonine protein kinase and ATR kinase inhibitors potentiate chemotherapy and radiation. The ATR kinase inhibitor VX-970 (NSC 780162) is in clinical development in combination with primary cytotoxic agents and as a monotherapy for tumors harboring specific mutations. Nucleotide excision repair (NER) is the sole mechanism of UV-induced DNA lesion repair in mammals. A single round of NER requires multiple components including seven core NER factors, xeroderma pigmentosum A-G (XPA-XPG), and many auxiliary effector proteins including ATR serine/threonine kinase. The ataxia telangiectasia mutated serine/threonine kinase (ATM)/checkpoint kinase 2 (CHEK2, best known as CHK2) and the ATM and Rad3-related serine/threonine kinase (ATR)/CHEK1 (best known as CHK1) cascades are the 2 major signaling pathways driving the DNA damage response (DDR), a network of processes crucial for the preservation of genomic stability that act as a barrier against tumorigenesis and tumor progression. |
| Research Areas |
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