| Catalog No. | Size | Price (USD) |
| 10279-MM17T-P-25 | 25 Tests | $162.92 |
| 10279-MM17T-P-100 | 100 Tests | $325.84 |
General Information
| Product name | Anti-AXL Antibody (PE), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human AXL |
| Immunogen | Recombinant Human AXL Protein (Catalog#10279-H08H) |
| Preparation | This product is a recombinant monoclonal antibody expressed from HEK293 cells and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Source | Monoclonal Mouse IgG1 Clone #17 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 5 μL/Test, 0.1 mg/mL |
| Conjugate | PE |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-ARK Antibody; Anti-AXL3 Antibody; Anti-JTK11 Antibody; Anti-Tyro7 Antibody; Anti-UFO Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Human AXL expression on DU145 cells. Cells were stained with PE-conjugated anti-Human AXL. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Human AXL Flow Cytometry (FC) 37102 |
| Image 1 URL | Source image |
Background Information
| Full Name | AXL receptor tyrosine kinase |
| Description | Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo. |
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