| Catalog No. | Size | Price (USD) |
| 10976-R004-50 | 50 µL | $177.58 |
| 10976-R004-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-CLEC-2 Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CLEC-2 |
| Immunogen | Recombinant Human CLEC1B / CLEC2 Protein (Catalog#10976-H07H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human CLEC1B / CLEC2 (rh CLEC1B / CLEC2; Catalog#10976-H07H; Gln 58-Pro 229; NP_057593.3). |
| Source | Monoclonal Rabbit IgG Clone #004 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-1810061I13Rik Antibody; Anti-CLEC-2 Antibody; Anti-CLEC2 Antibody; Anti-CLEC2B Antibody; Anti-PRO1384 Antibody; Anti-QDED721 Antibody; Anti-UNQ721/PRO1384 Antibody
Background Information
| Full Name | C-type lectin domain family 1, member B |
| Description | CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver. It acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. |
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