| Catalog No. | Size | Price (USD) |
| 10218-MM06-A-25 | 25 Tests | $133.30 |
| 10218-MM06-A-100 | 100 Tests | $414.71 |
General Information
| Product name | Anti-CSF3R/G-CSFR Antibody (APC), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CSF3R/G-CSFR |
| Immunogen | Recombinant Human G-CSFR / CD114 / CSF3R Protein (Catalog#10218-HCCH) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human G-CSFR / CD114 / CSF3R (rh G-CSFR / CD114 / CSF3R; Catalog#10218-HCCH; NP_000751.1; Met1-Pro621) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Source | Monoclonal Mouse IgG1 Clone #06 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Concentration | 10 μl/Test, 0.1 mg/ml |
| Conjugate | APC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Synonyms: Anti-CD114 Antibody; Anti-G-CSF-R Antibody; Anti-GCSFR Antibody; Anti-SCN7 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of anti-human GCSFR (CD114) on human whole blood granulocytes. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable granulocytes. |
| Image 1 Alt Text | Human G-CSF R/CD114/CSF3R Flow Cytometry (FC) 5167 |
| Image 1 URL | Source image |
Background Information
| Full Name | colony stimulating factor 3 receptor (granulocyte) |
| Description | Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis. |
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| References |
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