Anti-CXCL5 Antibody (Biotin), Mouse Monoclonal sinobiological 10889-MM14-B

$357.00
In stock
SKU
10889-MM14-B
Catalog No.SizePrice (USD)
10889-MM14-B-100100 µg$370.28

General Information

Product nameAnti-CXCL5 Antibody (Biotin), Mouse Monoclonal
Validated applicationsELISA (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CXCL5
ImmunogenRecombinant Human CXCL5 Protein (Catalog#10889-HNAE)
PreparationThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CXCL5 (rh CXCL5; Catalog#10889-HNAE; P42830; Arg45-Asn114). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and then biotinylated.
SourceMonoclonal Mouse IgG1 Clone #14
PurificationProtein A
Formulation0.2 μm filtered solution in PBS
ConjugateBiotin
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-ENA-78 Antibody; Anti-ENA78 Antibody; Anti-SCYB5 Antibody

Background Information

Full Namechemokine (C-X-C motif) ligand 5
DescriptionCXCL5 is a small cytokine belonging to the CXC chemokine family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL5 is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. It also can be detected in eosinophils, and can be inhibited with the type II interferon. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis. It stimulates the chemotaxis of neutrophils possesses angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.
Related Pathways
  • IL17 signaling pathway
References
  1. Dawes JM, et al. (2011) CXCL5 Mediates UVB Irradiation-Induced Pain. Sci Transl Med. 3(90): 90ra60.
  2. O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
  3. Persson T, et al. (2003) Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils. Clin Exp Allergy. 33(4):531-7.

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