| Catalog No. | Size | Price (USD) |
| 100973-T08-50 | 50 µL | $147.96 |
| 100973-T08-100 | 100 µL | $251.64 |
| 100973-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MSH6 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human, Cynomolgus, Mouse, Rat, Ferret |
| Specificity | Human, Cynomolgus, Mouse, Rat, Ferret |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the human MSH6 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the human MSH6, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-GTBP Antibody; Anti-GTMBP Antibody; Anti-HNPCC5 Antibody; Anti-HSAP Antibody; Anti-LYNCH5 Antibody; Anti-MMRCS3 Antibody; Anti-MSH-6 Antibody; Anti-p160 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining MSH6 in human rectal cancer with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human MSH6 / GTBP Immunohistochemistry(IHC) 3883 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining MSH6 in human rectal cancer with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections). |
| Image 2 Alt Text | Human MSH6 / GTBP Immunohistochemistry(IHC) 3885 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining MSH6 in human rectal cancer with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections). |
| Image 3 Alt Text | Human MSH6 Immunohistochemistry(IHC) 21238 |
| Image 3 URL | Source image |
| Image 4 Description | Immunochemical staining MSH6 in human rectal cancer with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections). |
| Image 4 Alt Text | Human MSH6 Immunohistochemistry(IHC) 21256 |
| Image 4 URL | Source image |
| Image 5 Description | Immunochemical staining MSH6 in human rectal cancer with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections). |
| Image 5 Alt Text | Human MSH6 Immunohistochemistry(IHC) 21260 |
| Image 5 URL | Source image |
Background Information
| Full Name | mutS homolog 6 |
| Description | MutS homolog 6 (MSH6) is one of the mismatch repair proteins and is encoded by the MSH6 gene, which is located on chromosome 2 and is 23,806 bp in length, including 10 exons and 83 untranslated regions. MutS homolog 6 (MSH6) is the major mismatch contacting component of the MSH2-MSH6 heterodimeric complex (MutSalpha) that mediates DNA mismatch repair (MMR) of simple mispairs and small insertion-deletion loops in eukaryotes. The MSH6 protein consists of 1,358 amino acid residues and forms a heterodimer with another mismatch repair protein, MSH2. The MSH2-MSH6 heterodimeric complex can recognize base-base substitution and single-base insertion/deletion mismatches. Germline mutations of MSH6 lead to high susceptibility to glioma, as well as some benign or malignant tumors in other organs. The MSH6 gene is one of the mismatch repair genes involved in Lynch syndrome and its mutations account for 10-20% of Lynch syndrome. |
| Research Areas |
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