Anti-Cystatin A Antibody, Rabbit Polyclonal sinobiological 10479-RP01

$143.00
In stock
SKU
10479-RP01
Catalog No.SizePrice (USD)
10479-RP01-100100 µL$147.96
10479-RP01-200200 µL$251.64
10479-RP01-400400 µL$355.32

General Information

Product nameAnti-Cystatin A Antibody, Rabbit Polyclonal
Validated applicationsELISA (FAQ Protocol), IHC-P (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman Cystatin A
ImmunogenRecombinant Human Cystatin A / CSTA protein (Catalog#10479-H07E)
PreparationProduced in rabbits immunized with purified, recombinant Human Cystatin A / CSTA (rh Cystatin A / CSTA; Catalog#10479-H07E; P01040; Ile 2-Phe 98). Total IgG was purified by Protein A affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-AREI Antibody; Anti-PSS4 Antibody; Anti-STF1 Antibody; Anti-STFA Antibody

Image / Experimental Information

Image 1 DescriptionImmunochemical staining of human CSTA in human tonsil with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Image 1 Alt TextHuman Cystatin A / CSTA Immunohistochemistry(IHC) 4337
Image 1 URLSource image

Background Information

Full Namecystatin A
DescriptionCystatin-A, also known as Cystatin-AS, Stefin-A and CSTA, is a cytoplasm protein which belongs to thecystatin family. Cystatin-A / CSTA is a cysteine proteinase inhibitor with a molecular mass of 11 kDa, and is located mainly in the keratohyaline granules of the stratum granulosum and the cornified envelope of the stratum corneum in the epidermis. The cystatins are a family of cysteine protease inhibitors with homology to chicken cystatin. Cystatins are physiological inhibitors of cysteine proteinases which are widely distributed in human tissues and fluids. Cystatins typically comprise about 115 amino acids, are largely acidic, contain four conserved cysteine residues known to form two disulfide bonds. Cystatins may be glycosylated and / or phosphorylated, with similarity to fetuins, kininogens, stefins, histidine-rich glycoproteins and cystatin-related proteins. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired inhibitory activity. Cystatins mainly inhibit peptidases belonging to peptidase families C1 (papain family) and C13 (legumain family).
References
  1. Machleidt W., et al. ,(1983), Protein inhibitors of cysteine proteinases. II. Primary structure of stefin, a cytosolic protein inhibitor of cysteine proteinases from human polymorphonuclear granulocytes. Hoppe-Seyler's Z. Physiol. Chem. 364:1481-1486.
  2. Takeda A., et al. , (1989), Comparative studies on the primary structure of human cystatin as from epidermis, liver, spleen, and leukocytes.J. Biochem. 105:986-991.
  3. Kartasova T., et al. ,(1987), Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes.Nucleic Acids Res. 15:5945-5962.

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