| Catalog No. | Size | Price (USD) |
| 10439-R033-50 | 50 µL | $177.58 |
| 10439-R033-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-Cystatin C Antibody, Rabbit Monoclonal |
| Validated applications | IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Cystatin C Has cross-reactivity in ELISA with Human CST5 No cross-reactivity in ELISA with Human CST6 Human Fetuin A |
| Immunogen | Recombinant Human Cystatin C / CST3 protein (Catalog#10439-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human Cystatin C / CST3 (rh Cystatin C / CST3; Catalog#10439-H08H; NP_000090.1; Ser27-Ala146). |
| Source | Monoclonal Rabbit IgG Clone #033 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ARMD11 Antibody; Anti-HEL-S-2 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CST3 in human kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human Cystatin C / CST3 Immunohistochemistry(IHC) 4342 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CST3 in human kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Image 2 Alt Text | Human Cystatin C / CST3 Immunohistochemistry(IHC) 4343 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human CST3 in human kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Image 3 Alt Text | Human Cystatin C Immunofluorescence(IF) 20333 |
| Image 3 URL | Source image |
Background Information
| Full Name | cystatin C |
| Description | Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect small reductions in glomerular filtration rate. The mature, active form of human cystatin C is a single non-glycosylated polypeptide chain consisting of 120 amino acid residues, with a molecular mass of 13,343-13,359 Da, and containing four characteristic disulfide-paired cysteine residues. Cystatin C is a low-molecular-weight protein that has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of Cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. In almost all the clinical studies, Cystatin C demonstrated a better diagnostic accuracy than serum creatinine in discriminating normal from impaired kidney function, but controversial results have been obtained by comparing this protein with other indices of kidney disease, especially serum creatinine-based equations, such as early atherosclerosis, Alzheimer's dementia, vascular aneurysms, hyperhomocysteinaemia and other neurodegenerative diseases. Cystatin C could be a useful clinical tool to identify HIV-infected persons. In addition, its expression is up-regulated in malignance of certain tumor progression. |
| References |
|
