Anti-B7-H3 Antibody, Rabbit Polyclonal sinobiological 201526-T32
$243.00
In stock
SKU
201526-T32
| Catalog No. | Size | Price (USD) |
| 201526-T32-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-B7-H3 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human B7-H3 |
| Immunogen | E. coli-derived Human B7-H3 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human B7-H3 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-B7-H3 Antibody; Anti-B7H3 Antibody; Anti-B7RP-2 Antibody; Anti-PSEC0249 Antibody; Anti-UNQ309/PRO352 Antibody
Image / Experimental Information
| Image 1 Description | Anti-B7-H3 rabbit polyclonal antibody at 1:500 dilution Lane A: 293T Whole Cell Lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:59 kDa |
| Image 1 Alt Text | Human B7-H3 Western blot (WB) 36730 |
| Image 1 URL | Source image |
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Background Information
| Full Name | CD276 molecule |
| Description | B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. |
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